EVALUATION OF THE EFFICACY OF IMMUNOMODULATING THERAPY FOR ACUTE OBSTRUCTIVE BRONCHITIS IN CHILDREN

Abstract

Acute obstructive bronchitis is very common among young children, often leading to frequent relapses and severe complications. Under the influence of an infectious factor in children, various immunological changes are often observed, the body's ability to develop full-fledged post-infection immunity is sharply reduced. The aim of the study was to evaluate the effectiveness of immunomodulatory therapy in children with acute obstructive bronchitis. 65 children with acute obstructive bronchitis were examined. The immunological study was carried out in the clinical laboratory of the SamMI clinic. The number of T-lymphocytes (CD3), T-helpers (CD4), T-suppressors (CD8), and B-lymphocytes (CD19) was determined by a modified method. The concentration of serum immunoglobulins A, M, G in peripheral blood was determined according to the method of Mancini et al. The phagocytic activity of neutrophils was studied using latex particles. Immunological examination was carried out taking into account the nature of therapy: the 1st group of patients received traditional treatment with the inclusion of T-activin, and the 2nd group of children received only traditional treatment. It was found that the use of T-activin in the complex therapy of children with acute obstructive bronchitis increases the effectiveness of treatment, contributes to the normalization of the immune status and prevents the development of relapses of the disease.