PROTECTIVE EFFECT OF PROBIOTIC SUPPLEMENTATION IN DIABETIC PREGNANT FEMALE MICE ON BLOOD SUGAR AND LIPIDS

Abstract

The study was conducted in the animal house of the College of Veterinary Medicine / Tikrit University and in the laboratories of the General Company for the Pharmaceutical Industry and Medical Appliances / Samarra. for the period from October/  2020 until the end of April/ 2021. It included the production of therapeutic yoghurt with the addition of a mixture of probiotic supplements Lactobacillus Casei, Lb. planetarium, Lb. acidophilus and Bifidobacterium. Bifiduem) and a second starter of two types of probiotic (Bif. Bifiduem and Lb. casei) with some fruits (cranberry and strawberry) and therapeutic drugs (Gliclazide and Metformin), to know their effect on some physiological and biochemical parameters such as measuring blood sugar values, total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL). very low-density lipoproteins (VLDL) and high-density lipoproteins (HDL) of female laboratory mice with alloxan-induced diabetes, as well as the effect of female mice with diabetes on their offspring and conducting the same criteria mentioned above.The results showed a significant increase (p<0.05) in blood sugar concentrations (156.4) mg/dL, TC (195.4) mg/dL, TG (159.6) mg/dL, LDL (150) mg/dL, VLDL (31.92) mg/dL, and a significant decrease in HDL (35) mg/dL, while female mice were treated with alloxan.