THE ROLE OF HYPERHOMOCYTEINEMIA IN THE DEVELOPMENT OF COGNITIVE DISORDERS IN CHRONIC BRAIN ISCHEMIA

Abstract

Chronic ischemia of the brain (dyscirculatory encephalopathy) in terms of prevalence occupies a leading place in the structure of cerebrovascular diseases [P. Kamchatnov P. R., et al., 2008]. One of the dominant manifestations of chronic cerebral ischemia is a violation of cognitive functions, leading to social disadaptation of patients [NN Yakhno, 2006]. Currently, there are conflicting data in the literature on the relationship of hyperhomocysteinemia with cognitive impairment and on the effect of hyperhomocysteinemia on the progression of cognitive disorders [Kim J., et.al., 2007]. There is also an opinion that denies the existence of a relationship between hyperhomocysteinemia and the increase in cognitive disorders. Many articles and dissertations by international scientists were analyzed, which were based on various books, dissertations, as well as electronic journals.