ANALYSIS OF THE RELATIONSHIP OF THE HLA-PHENOTYPE WITH THE LEVEL OF IMMUNOREACTIVITY OF THE ORGANISM

Authors

  • Dushanova Gavkhar Abdukarimovna Associate Professor, Department of Genetics and Biotechnology, Samarkand State University
  • Nabieva Farangiz Sadriddinovna Assistant, Department of Clinical and Laboratory Diagnostics, Samarkand State Medical University
  • Rayimova Fariza Salimovna Assistant, Department of Genetics and Biotechnology, Samarkand State University
  • Olimjonova Sadoqat G’ulomjon qizi Assistant, Department of Genetics and Biotechnology, Samarkand State University

DOI:

https://doi.org/10.17605/OSF.IO/MUHWJ

Keywords:

HLA, markers, antigens, immune response, cytokines

Abstract

An analysis of the relationship between the HLA phenotype of the studied individuals and the studied parameters of the immune status made it possible to establish the association of the HLA-DR4 and DR5 antigens with the level of the circulating pool of T-lymphocytes, A30- with the content of NCC in the peripheral blood, the presence of the HLA-antigen B35 in the phenotype of the studied individuals was associated with a reduced content and HLA-A30-with a high content of the main classes of serum immunoglobulins. The conducted studies indicate the role of HLA-associated genetic control in the level of immunoreactivity of the studied population. For the first time, HLA markers were identified that characterize the quantitative imbalance of the immune system.

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Published

2022-09-20

How to Cite

Dushanova Gavkhar Abdukarimovna, Nabieva Farangiz Sadriddinovna, Rayimova Fariza Salimovna, & Olimjonova Sadoqat G’ulomjon qizi. (2022). ANALYSIS OF THE RELATIONSHIP OF THE HLA-PHENOTYPE WITH THE LEVEL OF IMMUNOREACTIVITY OF THE ORGANISM. Web of Scientist: International Scientific Research Journal, 3(9), 429–438. https://doi.org/10.17605/OSF.IO/MUHWJ

Issue

Vol. 3 No. 9 (2022): wos

Section

Articles

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