EFFECTS OF PROTON PUMP INHIBITORS ON THE DEGREE OF DEVELOPMENT OF LIVER ENCEPHALOPATHY IN PATIENTS WITH LIVER CIRROSIS

Abstract

In this study, we attempted to determine whether proton pump inhibitor (PPI) use in patients with hepatic encephalopathy was predisposed to more severe stages of hepatic encephalopathy according to West Haven criteria. We found that chronic use of PPIs in patients with cirrhosis of the liver and gastroduodenal pathology was associated with significantly higher mean West Haven criteria for hepatic encephalopathy compared with patients who did not use PPIs. Our data also showed that patients with cirrhosis of the liver receiving PPIs have longer hospital stays, with increased morbidity and mortality during their hospital stay.