DIAGNOSIS OF HELICOBACTER PYLORI AMONG GASTROINTESTINAL PATIENTS IN WAIST PROVINCE DURING 2022-2023

Abstract

Background: Helicobacter pylori, also known as H. pylori infection, is a growing global health concern and affects nearly 50% of the world's population. This persistent Infection remains a significant public health challenge. The objectives of this study are to identify the presence of Helicobacter pylori in various clinical cases of gastrointestinal disorders by using several biochemical tests and non-invasive procedures.
Material and method: This study was conducted in Waist Governorate and included 119 patients. Their ages ranged between 12 and 62 years old, and they were males and females. Blood specimens were obtained from patients in Al- Karama Teaching Hospital. Saliva and some blood specimens were obtained from the outpatient clinic. Based on the clinical Diagnosis according to antibody, stool antigen, and urea breath test to detect H. pylori infection
Results: the study found the gastroenteritis patients according to type H. Pylori test with the highest per cent 74.60% positive to serum antibody, and negative 57.60% regarding stool antigen, and highest negative 64.40% to urea breath test. The findings reveal significant relationships between different age groups and the levels of Serum antibody (p= .016), Stool antigen (p= .000), and Urea breath test (p= .008). The study found high sensitivity and high specificity in the urea breath test at AUC (0.936) SD error (0.025) and stool antigen at AUC 0.875, SD error 0.052 with P.value <0.05 compared with serum antibody at AUC 0.741, SD error 0.08 with P.value 0.004 conclusion: The study indicted significant increase of H. Pylori infection with increase age of gastrointestinal patients of while observed no difference between males and females about these Infection, the urea breath test has high sensitive and specific for detecting H. Pylori infection than other non-invasive test.