CLINICAL PHARMACOLOGICAL APPROACH TO THE USE OF ANTIBACTERIAL DRUGS IN GASTROINTESTINAL ULCER DISEASE

Abstract

This article examines the clinical-pharmacological principles guiding the use of antibacterial drugs in the management of gastrointestinal ulcer disease, with particular emphasis on Helicobacter pylori–associated peptic ulcers. Modern therapeutic strategies are explored through evidence-based approaches that integrate pathogen-oriented treatment, drug–drug interaction assessment, pharmacokinetic optimization, individual patient risk profiling, and antibiotic resistance prevention. The review highlights dosing principles, eradication regimens, precautions in high-risk patient groups, and the role of combined therapy involving proton-pump inhibitors and mucosal protectants. Contemporary international guidelines and experimental findings are utilized to demonstrate how antibacterial therapy can be rationally tailored to improve healing outcomes while minimizing adverse effects.