CLINICAL PHARMACOLOGICAL APPROACH TO THE USE OF ANTIHYPERTENSIVE DRUGS IN PREGNANT WOMEN

Abstract

This article examines the clinical-pharmacological principles guiding the safe and rational use of antihypertensive drugs in pregnant women. Hypertensive disorders during pregnancy remain a major cause of maternal and perinatal morbidity, requiring carefully balanced therapeutic decisions that consider maternal benefits and fetal safety. The study discusses pathophysiological mechanisms of hypertension in pregnancy, drug selection strategies, safety classifications, pharmacokinetics during gestation, and evidence-based recommendations for treatment. Special emphasis is placed on international guidelines, risk–benefit analysis, teratogenic considerations, and the long-term effects of antihypertensive therapy on maternal cardiovascular health.