EFFECTIVENESS OF STATINS IN THE PREVENTION OF ISCHEMIC HEART DISEASE

Abstract

The main cause of the development of ischemic diseases of the cardiovascular system is atherosclerosis. Other less common causes of coronary heart disease include pathology of the microcirculatory bed of the myocardium and coronary vasospasm.
According to the WHO definition, atherosclerosis is a variable combination of changes in the inner lining (intima) of the arteries, including the accumulation of lipids, complex carbohydrates, fibrous tissue, blood components, calcification and concomitant changes in the middle shell (media). For a long time, atherosclerosis can proceed asymptomatically, only eventually leading to angina pectoris, chronic cerebrovascular insufficiency, intermittent lameness, or to the immediate manifestation of myocardial infarction, ischemic stroke, sudden death. As a result of the formation and growth of ASB, gradual stenosis of the coronary, cerebral and other arteries occurs. However, often the first manifestation of coronary heart disease is a myocardial infarction or sudden death due to the rupture of an atherosclerotic plaque that does not obstruct the lumen of the artery.