ASPIRIN-INDUCED ASTHMA: FEATURES OF DIAGNOSIS AND TREATMENT

Abstract

Hypersensitivity to acetylsalicylic acid (ASA) and nonsteroidal anti-inflammatory drugs (NSAIDs) is a pressing problem for physicians of many specialties who use these drugs for a wide range of diseases. Aspirin-induced asthma often manifests itself as a triad: bronchial asthma, hypersensitivity to ASA and NSAIDs, polypous rhinosinusitis. Aspirin-induced respiratory disease may be limited to isolated polypous and, less commonly, non-polypous rhinosinusitis. Diagnosis is based on anamnestic and clinical signs. In the absence of a typical anamnesis, the diagnosis of hypersensitivity to NSAIDs is confirmed using a provocative test. Treatment includes anti-inflammatory drugs (glucocorticosteroids, antileukotriene drugs), exclusion/limitation of triggers and, according to strict indications, desensitization of ASA, as well as a new direction – therapy with biological drugs (omalizumab, etc.).