PECULIARITIES OF THE USE OF ANTI-INFLAMMATORY DRUGS IN CHILDREN

Abstract

This article analyzes the clinical and pharmacological characteristics of anti-inflammatory drug use in children, focusing on age-related physiological differences, pharmacokinetic variability, safety considerations, and dosing principles. Special attention is given to nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and selective anti-inflammatory agents frequently used in pediatric practice. The article highlights the risks of gastrointestinal, renal, and cardiovascular complications, emphasizing the importance of individualized therapy, weight-based dosing, and evidence-based monitoring strategies. Modern clinical guidelines and international recommendations regarding pediatric anti-inflammatory therapy are also reviewed.