CLINICAL PHARMACOLOGICAL APPROACH TO ANTIBIOTIC USE IN CHILDREN

Abstract

This article examines the clinical-pharmacological principles governing rational antibiotic use in pediatric practice, emphasizing dosage individualization, age-related pharmacokinetics, and prevention of antimicrobial resistance. It highlights the specific challenges of antibiotic therapy in neonates, infants, and young children, considering their unique metabolic pathways, immune system immaturity, and susceptibility to adverse drug reactions. The paper also outlines evidence-based protocols, global recommendations, and the risks associated with inappropriate prescribing. The discussion includes monitoring strategies, drug-drug interactions, and international best practices aimed at optimizing clinical outcomes and ensuring safe, effective therapy.