THE IMPACT OF BODY MASS INDEX ON THE HORMONAL AND IMMUNOLOGICAL STATUS OF ADOLESCENT GIRLS WITH MENSTRUAL CYCLE DISORDERS

Authors

  • Kamalov T. M. Samarkand State Medical University, Samarkand, Uzbekistan
  • Musakhodjaeva D. A. Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan
  • Muzafarova S. A. Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan
  • Azizova Z. Sh. Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan
  • Ruzimurodov N. F. Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan

Keywords:

Girls, teenagers, menstrual cycle, imbalance, testosterone, adipokines, hirsutism, hormones, body mass index.

Abstract

A study was conducted to examine the influence of body mass index (BMI) on the hormonal and immunological status of adolescent girls with menstrual cycle disorders. The research revealed that in the group of girls with high BMI and menstrual cycle disorders, hyperandrogenism, hyperinsulinemia, and reduced adiponectin levels were observed, accompanied by systemic inflammation and probable disruption of the hypothalamic-pituitary-ovarian axis. In contrast, the group of girls with low BMI and menstrual cycle disorders exhibited signs of hypoestrogenism, decreased leptin, and suppression of reproductive function, likely due to energy deficiency.

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Published

2025-05-09

Issue

Vol. 6 No. 5 (2025): wos

Section

Articles

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Copyright (c) 2025 Web of Scientist: International Scientific Research Journal

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.